Pharmaceutical Instruments

Antec Electrochemical Cells

VT03 highest sensitivity flow cell

  • Quick stabilization
  • Long lifetime (5 year warranty)
  • Down to 5 nL working volume
  • Easy maintenance
Antec VT03 Cell
After extensive testing, it was determined that the confined wall-jet configuration gave excellent results. In addition, we found that the qualilty of the material used and the finishing process of the working electrode greatly affected the performance of the EC detector.

While competitor flow cells deteriorate during use, the performance of the VT03 flow cell increases with use. The VT03 requires unusually short stabilization times: trace analysis within half an hour after start up can be expected. We have so much confidence in our VT03 flow cell that we warrant the glassy carbon flow cell for a period of 5 years.

The VT03 is available with working electrode materials of glassy carbon, platinum, gold, and silver. A selection of working electrodes of 3, 2 and 0.7 mm diameter together with salt bridge, ISAAC and HyREF reference electrodes ensures compatibility with any type of HPLC analysis.




VT03 cell

Type

Confined wall-jet design
working volume determined by spacer thickness and WE diameter

Spacers

25, 50 or 120 µm, stackable

WE diameters

0.7 - 3 mm (2 mm standard)

Cell volume

11 nl minimum

WE electrodes

Glassy carbon, gold, platinum, silver and copper

Reference electrodes

salt-bridge Ag/AgCl; in-situ Ag/AgCl (ISAAC); HyREF™

Auxiliary electrode

stainless steel

Wetted materials

PCTFE, FEP, 316-SS, Viton, Silver, Silver chloride and WE

Max. pressure

40 psi / 2.8 bar


Cells with Glassy Carbon Electrodes

Part no Description
110.4105
110.4205
110.4305

110.4115
110.4215
110.4315

111.4105
111.4205
111.4305
VT03 flow cell, 3 mm GC WE, sb REF
VT03 flow cell, 3 mm GC WE, ISAAC
VT03 flow cell, 3 mm GC WE, HyREF

VT03 flow cell, 2 mm GC WE, sb REF
VT03 flow cell, 2 mm GC WE, ISAAC
VT03 flow cell, 2 mm GC WE, HyREF

µ-VT03 flow cell, 0.7 mm GC WE, sb REF
µ-VT03 flow cell, 0.7 mm GC WE, ISAAC
µ-VT03 flow cell, 0.7 mm GC WE, HyREF

 

 

 

 

 

 

 

 

 

 

Cells with Metal Electrodes

Part no Description
110.4120
110.4220
110.4320

110.4125
110.4225
110.4325

110.4130
110.4230
110.4330

110.4135
110.4235
110.4335
VT03 flow cell, 3 mm Pt WE, sb REF 
VT03 flow cell, 3 mm Pt WE, ISAAC 
VT03 flow cell, 3 mm Pt WE, HyREF

VT03 flow cell, 3 mm Au WE, sb REF 
VT03 flow cell, 3 mm Au WE, ISAAC
VT03 flow cell, 3 mm Au WE, HyREF

VT03 flow cell, 2 mm Ag WE, sb REF 
VT03 flow cell, 2 mm Ag WE, ISAAC
VT03 flow cell, 2 mm Ag WE, HyREF

VT03 flow cell, 3 mm Cu WE, sb REF 
VT03 flow cell, 3 mm Cu WE, ISAAC
VT03 flow cell, 3 mm Cu WE, HyREF

 











 

 

Flexcell

The most versatile flow cell for LC-ECD

The name Flexcell is chosen since it emphasizes the versatility and serviceability of this thin-layer flow cell in the Antec program. With its unrivaled design working electrodes can be serviced or replaced in a few minutes.
  • Exchangeable working electrode
  • Working Electrodes: GC, Pt, Au, Ag, MD
  • Low cost of ownership




The low cost of ownership is attributed to the replacement of only the working electrode disc.
The same holds for switching electrode material for different applications using the same flow cell.

This makes the Flexcell suitable for all sorts of electrochemical analyses like the usual biogenic amines (glassy carbon), but also carbohydrates (gold), peroxides (platinum), halides (silver), sulfides (Magic Diamond) etc.



Applications
The Flexcell properties are particularly usefull in applications using metal working electrodes. A typical example is the pulsed amperometric detection of carbohydrates, where consumption of the gold working electrode occurs. Renewal of the gold electrode is done in a few minutes when the erosion has become unacceptable. The total cell volume is less than 1 µL, which makes the Flexcell suitable as an electrochemical reactor in-line with other detectors.

Flexcell specifications

Spacers

50 or 100 µm, stackable

WE diameters

8 mm

Cell volume

0.75 µl

WE electrodes

Glassy carbon, Magic DiamondTM, gold, platinum, silver and copper

Reference electrodes

salt-bridge Ag/AgCl; in-situ Ag/AgCl (ISAAC); HyREF™

Auxiliary electrode

Graphite

Wetted materials

PCTFE, FEP, 316-SS, Viton, Silver, Silver chloride and WE

Max. presure

40 psi / 2.8 bar

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Flexcells ordering

Part no Description
102.4305
102.4305
102.4320
102.4325
102.4330

102.4105
102.4120
102.4125
102.4130

102.4205
102.4220
102.4225
102.4230
Flexcell MD HyREF
Flexcell GC HyREF
Flexcell Pt HyREF
Flexcell Au HyREF
Flexcell Ag HyREF

Flexcell GC sb
Flexcell Pt sb
Flexcell Au sb
Flexcell Ag sb

Flexcell GC ISAAC
Flexcell Pt ISAAC
Flexcell Au ISAAC
Flexcell Ag ISAAC

 

 

 

 

 

 

 

 

 

 

 

 

Electrodes

Part no Description
102.5007
102.5022
102.5027
102.5032
102.5037
102.5050
Flexcell WE disc GC (glassy carbon)
Flexcell WE disc Pt (platinum)
Flexcell WE disc Au (gold)
Flexcell WE disc Ag (silver)
Flexcell WE disc Cu (copper)
Flexcell WE disc MD (magic diamond)


ReactorCell

ReactorCell™ for microbore LC
The DECADE II with dual cell control (DCC) can be equipped with an additional flow cell, such as a ReactorCell for µ-bore LC-EC. The cell is positioned between the chromatographic column and the detection flow cell. A potential is applied that converts the analyte of interest into an electroactive species that can be detected by the detection flow cell.

  • Electrochemical oxidation / activation / reduction
  • Down to 0.7 µL cell volume
  • Easy exchange of working electrodes
  • Zero sample adsorption


This approach is usually applied to obtain a better selectivity or sensitivity, and is only applicable for analytes with reversible electrochemical reaction properties. An example is the pre-reduction followed by oxidative detection of vitamin K (Antec's application note 218-005).

EC upfront MS is another field of application for the ReactorCell. Already in the early nineties reports appeared describing the use of HPLC in combination with electrochemical detection and mass spectrometry for signal enhancement  of PAH's and cleavage of peptides.


More recently the on-line coupling of EC with LC/MS has shown great potential for the investigation of drug metabolism. It offers fast electrochemical synthesis of drug metabolites for reliable quantification by MS.

ReactorCell and electrodes

Part no Description
210.0040

210.5007
210.5022
210.5027
210.5050
ReactorCell kit with Pt, Au, MD, GC electrode (each 1 x)

Pt working electrode
Au working electrode
MD working electrode
GC working electrod









Anetx Roxy with microbore electrochemical cell


Reactor cell specifications

Spacers

50 or 100 µm, stackable

WE diameters

8 mm

Cell volume

0.75 µl

WE electrodes

Glassy carbon, Magic DiamondTM, gold, platinum, silver and copper

Reference electrodes

salt-bridge Ag/AgCl; in-situ Ag/AgCl (ISAAC); HyREF™

Auxiliary electrode

Graphite

Wetted materials

PCTFE, FEP, 316-SS, Viton, Silver, Silver chloride and WE

Max. pressure

40 psi / 2.8 bar

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

µPrepCell

µ-PrepCell™: Quick and clean metabolite synthesizer!

Structural elucidation of reactive metabolites plays an important role in drug development. Xenobiotics such as drugs are often metabolized by cytochrome P450 enzymes (CYP) to oxidative metabolites. A number of publications have shown that the vivo formation of these metabolites can be mimicked in vitro by electrochemical oxidation in a flow cell.
  • Synthesizer for metabolites
  • Quick and clean alternative for in-vivo studies
  • Synthesize micrograms of metabolites
  • Collect fractions for MS or NMR
  • High efficiency conversion

Generating these metabolites in vitro has a number of advantages over in vivo formation, most important: it is much quicker and cleaner. Metabolites are formed instantaneously in a well defined matrix.


The µ-PrepCell is designed to synthesize micrograms of metabolites in a short period of time. The active surface of the working electrode is about 10 times the size of a standard cell, and guarantees a significantly higher efficiency in formation of reactive metabolites.


The cell can be used in the ROXY EC system for off-line collection of metabolites. Flow rate and working potential can be optimized using the Dialogue software.

 

The µ-PrepCell has a diamond film electrode which facilitates high working potentials up to 4.9 Volt for even the most demanding reaction conditions.

The HyREF reference electrode is maintenance free and the stainless steel spacer is convenient to handle. In other words, the µ-PrepCell is designed for performance and offers a quick and clean alternative for in vitro methods.

µ-PrepCell and electrodes

Part no Description
204.4300
204.5007
204.5050
µ-PrepCell kit with MD and GC electrode
WE GC for µ-PrepCell
WE MD for µ-PrepCell






µ-PrepCell specifications

Spacers

50 or 100 µm, stackable

WE diameters

12 x 30 mm

Cell volume

12 µl minimum

WE electrodes

Glassy carbon, Magic Diamond™

Reference electrodes

HyREF™

Auxiliary electrode

Titanium

Wetted materials

PCTFE, PEEK, Titanium, Viton, Palladium, and WE

Max. pressure

25 bar (GC electrode) , 50 bar (with MD electrode)




















Produktgruppe

Pharmaceutical

Environmental

Clinical/Forensic

Instruments

EC systems

Kontakt

Biolab A/S
Sindalsvej 29
8240 Risskkov
Telefon: 86 21 28 66
E-mail: sales@biolab.dk